The LDL receptor.
نویسندگان
چکیده
In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.
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ورودعنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 29 4 شماره
صفحات -
تاریخ انتشار 2009